5Z-7-Oxozeaenol
作者：齊岳
發(fā)布時(shí)間：2023-08-23
09:15:52
點(diǎn)擊數(shù)：
產(chǎn)品名稱：5Z-7-Oxozeaenol
產(chǎn)品描述：
| 結(jié)構(gòu)類型 | 天然產(chǎn)物 > 其他 |
| 產(chǎn)品描述 | 5Z-7-Oxozeaenol is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM. |
| 靶點(diǎn)活性 | FLT3:170 nM, VEGFR-2:52 nM, PDGFR-β:340 nM, VEGFR-3:110 nM, MEK1:411 nM, TAK1:8.1 nM, B-RAF VE:6300 nM, Src:6600 nM |
| 體外活性 | 5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3]. |
| 別名 | LL-Z 1640-2, L783279, FR148083 |
| 分子量 | 362.37 |
| 分子式 | C19H22O7 |
| CAS No. | 253863-19-3 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 40 mg/mL (110.38 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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