PD180970
產品名稱:PD180970
產品描述:
產品描述 | PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies about chronic myelogenous leukemia. |
靶點活性 | KIT:50 nM, Src:0.8 nM, Bcr-Abl:5 nM (Ip210Bcr-Ablkinase) |
體外活性 | In K562 cells, PD180970 (0.5 μM) induces apoptosis and causes cell death. The IC50 values are 170, 80, and 80 nM for the tyrosine phosphorylation of p210Bcr-Abl, Gab2, and CrkL. PD180970 significantly inhibits the purified recombinant Abl tyrosine kinase activity with an IC50 of 2.2 nM[1]. In the human K562 CML cells, PD180970 inhibits the activity of Stat5 DNA-binding with an IC50 of 5 nM[2]. |
體內活性 | In Male C57BL/6J mice injected with MPTP, intraperitonial injection of PD180970 (5?mg/kg) decreased number of activated microglia on activation by MPTP and reduces the Iba1 expression intensity in activated microglia[1]. |
別名 | PD 180970 |
分子量 | 429.27 |
分子式 | C21H15Cl2FN4O |
CAS No. | 287204-45-9 |
存儲
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 90.0 mg/mL (209.7 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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