Lariciresinol
作者：齊岳
發(fā)布時(shí)間：2023-08-23
09:38:10
點(diǎn)擊數(shù)：
產(chǎn)品名稱：Lariciresinol
產(chǎn)品描述：
| 植物來(lái)源 | 天然產(chǎn)物 > 大戟科 > 葉下珠屬 |
| 產(chǎn)品描述 | Lariciresinol is an enterolignan precursor, it possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious diseases in humans. Dietary lariciresinol can attenuate mammary tumor growth and reduce blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats. |
| 體外活性 | In this study, the antifungal properties and mode of action of Lariciresinol were investigated. Lariciresinol displays potent antifungal properties against several human pathogenic fungal strains without hemolytic effects on human erythrocytes. To understand the antifungal mechanism of action of Lariciresinol, the membrane interactions of Lariciresinol were examined. Fluorescence analysis using the membrane probe 3,3'-diethylthio-dicarbocyanine iodide (DiSC(3)-5) and 1,6-diphenyl-1,3,5-hexatriene (DPH), as well as a flow cytometric analysis with propidium iodide (PI), a membrane-impermeable dye, indicated that Lariciresinol was associated with lipid bilayers and induced membrane permeabilization. |
| 別名 | (+)-落葉松樹(shù)脂醇 |
| 分子量 | 360.406 |
| 分子式 | C20H24O6 |
| CAS No. | 27003-73-2 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 55 mg/ml (152.61 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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