Desmethylanethol trithione
作者：齊岳
發(fā)布時間：2023-08-25
09:08:35
點擊數(shù)：
產(chǎn)品名稱：Desmethylanethol trithione
產(chǎn)品描述：
| 產(chǎn)品描述 | ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke. |
| 體外活性 | In glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. |
| 別名 | ADT-OH |
| 分子量 | 226.33 |
| 分子式 | C9H6OS3 |
| CAS No. | 18274-81-2 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 45 mg/mL (198.82 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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