Chelidonic acid
作者：齊岳
發(fā)布時(shí)間：2023-08-29
13:40:53
點(diǎn)擊數(shù)：
產(chǎn)品名稱：Chelidonic acid
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 罌粟科 > 白屈菜屬 |
| 結(jié)構(gòu)類型 | 天然產(chǎn)物 > 其他 |
| 產(chǎn)品描述 | Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. |
| 靶點(diǎn)活性 | Glutamate decarboxylase:1.2 μM (Ki) |
| 體內(nèi)活性 | Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice[3]. Chelidonic acid may attenuate allergic reactions by inhibiting caspase-1 activity. |
| 動(dòng)物實(shí)驗(yàn) | female BALB/c mice was Maintained 6-week-old under pathogen-free conditions.?Sensitized mice on days 1, 5, and 14 by intraperitoneal ?injection of 100 μg OVA emulsified in 20 mg aluminum hydroxide and we challenged mice with 1.5 mg OVA.?Chelidonic acid was administrated orally before intranasal .?OVA challenge for 10 days.?Nasal symptoms were evaluated by counting the number of nasal rubs that occurred in the 10 min after OVA. provocation at 10 days after challenge. |
| 別名 | γ-Pyrone-2,6-dicarboxylic acid, 白屈菜酸, Jerva acid, Jervaic acid |
| 分子量 | 184.103 |
| 分子式 | C7H4O6 |
| CAS No. | 99-32-1 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 4 mg/mL (21.72 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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