Evocarpine
作者：齊岳
發(fā)布時(shí)間：2023-08-30
09:02:48
點(diǎn)擊數(shù)：
產(chǎn)品名稱：Evocarpine
產(chǎn)品描述：
| 植物來源 | 天然產(chǎn)物 > 蕓香科 > 吳茱萸屬 |
| 結(jié)構(gòu)類型 | 天然產(chǎn)物 > 生物堿 |
| 產(chǎn)品描述 | Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels. |
| 體外活性 | The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and Evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic effects were concluded from fractional inhibitory concentration (FICI) values. Interaction energies of the compounds were calculated using GLUE docking module implemented in GRID. 1 and 2 exhibited weak inhibition of rapidly growing mycobacteria, however, 1 was active against Myco. tuberculosis H37Rv (MIC = 10 mg l(-1) ) while 2 was inactive. Both 1 and 2 showed a marked antagonistic effect on the susceptibility of different mycobacterial strains to 3 giving FICI values between 5 and 9. The interaction energies between compounds 1 and 2 with compound 3 suggested the possibility of complex formation in solution[1] |
| 分子量 | 339.51 |
| 分子式 | C23H33NO |
| CAS No. | 15266-38-3 |
存儲(chǔ)
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 50 mg/mL (147.27 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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