Inecalcitol
作者：齊岳
發(fā)布時間：2023-08-30
09:02:46
點擊數(shù)：
產(chǎn)品名稱：Inecalcitol
產(chǎn)品描述：
| 產(chǎn)品描述 | Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM. |
| 靶點活性 | vitamin D3:0.53 nM(Kd) |
| 體外活性 | A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow[1]. |
| 體內(nèi)活性 | Inecalcitol maximal tolerated dose (MTD) by intraperitoneal (i.p.) administration was 30 μg/mouse (1,300 μg/kg) three times per week, while we previously found that the MTD of 1,25(OH)(2) D(3) is 0.0625 μg/mouse; therefore, inecalcitol is 480 times less hypercalcemic than 1,25OH2 D3[1]. Inecalcitol inhibits androgen-responsive prostate cancer growth in vivo. |
| 別名 | TX-522, TX522, TX 522, 伊奈骨化醇 |
| 分子量 | 400.59 |
| 分子式 | C26H40O3 |
| CAS No. | 163217-09-2 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 55 mg/ml (137.3 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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