SAR131675
作者：齊岳
發布時間：2023-08-23
09:38:02
點擊數：
產品名稱：SAR131675
產品描述：
| 產品描述 | SAR 131675 is a potent and selective?VEGFR3?inhibitor with an?IC50?of 23 nM. |
| 靶點活性 | VEGFR3:23 nM |
| 體外活性 | KU-0060648 exhibits differential effects on growth inhibition, but is not profoundly cytotoxic in a panel of human cancer cell lines. It inhibits DNA-PK and PI-3K with greater potency in MCF7 than SW620 cell using cell-based assays. Five-day exposure to 1 mM KU-0060648 inhibits cell proliferation by more than 95% in MCF7 cells but only by 55% in SW620 cells. In clonogenic survival assays, KU-0060648 increases the cytotoxicity of etoposide and doxorubicin across the panel of DNA-PKcs-proficient cells, but not in DNA-PKcs-deficient cells, confirming that enhanced cytotoxicity of the topoisomerase II poisons etoposide and doxorubicin is due to DNA-PK inhibition. [1] |
| 別名 | SAR 131675 |
| 分子量 | 358.4 |
| 分子式 | C18H22N4O4 |
| CAS No. | 1433953-83-3 |
存儲
store at low temperture | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: <1 mg/mL
DMSO: 16.67 mg/mL (46.51 mM),ultrasonic and adjust pH to 2 with HCl
H2O: <1 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介紹：
西安齊岳生物科技有限公司是集化學科研和定制與一體的高科技化學公司。業務范圍包括化學試劑和產品的研發、生產、銷售等。涉及產品為通用試劑的分銷、非通用試劑的定制與研發，涵蓋生物科技、化學品、中間體和化工材料等領域。
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