Y15
作者：齊岳
發布時間：2023-08-24
09:17:26
點擊數：
產品名稱：Y15
產品描述：
| 產品描述 | Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
| 體外活性 | Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1]. |
| 細胞實驗 | Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour. |
| 別名 | 1,2,4,5-苯四胺四鹽酸鹽, FAK inhibitor Y15, 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14 |
| 分子量 | 284.01 |
| 分子式 | C6H14Cl4N4 |
| CAS No. | 4506-66-5 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 59 mg/mL (207.74 mM),Need ultrasonic and warming
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介紹：
西安齊岳生物科技有限公司是集化學科研和定制與一體的高科技化學公司。業務范圍包括化學試劑和產品的研發、生產、銷售等。涉及產品為通用試劑的分銷、非通用試劑的定制與研發，涵蓋生物科技、化學品、中間體和化工材料等領域。
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