Tolimidone
作者：齊岳
發布時間：2023-08-25
09:10:27
點擊數：
產品名稱：Tolimidone
產品描述：
| 產品描述 | MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals. |
| 靶點活性 | Lyn:63 nM(EC50) |
| 體外活性 | In an in vitro broad kinase screen MLR-1023 activated the nonreceptor-linked Src-related tyrosine kinase Lyn. MLR-1023 increased the Vmax of Lyn with an EC50 of 63 nM. This Lyn kinase activation was ATP binding site independent, indicating that MLR-1023 regulated the kinase through an allosteric mechanism[1]. |
| 體內活性 | MLR-1023-mediated blood glucose lowering depends on Lyn kinase activity[1]. MLR-1023 is an insulin receptor-potentiating agent that produces a rapid-onset and durable blood glucose-lowering activity in diabetic animals[2]. |
| 細胞實驗 | Adipocyte differentiation is assessed in mouse 3T3-L1 cells after 8 days of incubation with MLR-1023 or rosiglitazone (10 μM).(Only for Reference) |
| 別名 | 托利咪酮, NSC 314335, CP-26154, MLR-1023 |
| 分子量 | 202.213 |
| 分子式 | C11H10N2O2 |
| CAS No. | 41964-07-2 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 20.2 mg/mL (100 mM)
Ethanol: 4 mg/mL (20 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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