Floxuridine
作者：齊岳
發(fā)布時間：2023-08-30
09:00:40
點擊數(shù)：
產(chǎn)品名稱：Floxuridine
產(chǎn)品描述：
| 產(chǎn)品描述 | Floxuridine is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. |
| 體外活性 | Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5'-O-mono amino acid ester prodrugs. [1] Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. [2] Floxuridine significantly inhibits the uptake of both [(3)H]-inosine and [(3)H]-adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). [3] Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon's capsule fibroblasts in vitro. [4] Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction. [5] |
| 別名 | 氟尿苷, 5-Fluorouracil 2'-deoxyriboside, FUDR, NSC 27640, Deoxyfluorouridine |
| 分子量 | 246.19 |
| 分子式 | C9H11FN2O5 |
| CAS No. | 50-91-9 |
存儲
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 24.6 mg/mL (100 mM)
DMSO: 24.6 mg/mL (100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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